HATASO Journal Management System

Volume 6,Issue 2, 2020

Volume 6, Issue 2, Year 2020

Molecular Docking Studies of Podophyllotoxin and Its Derivatives against Metabolic Enzymes Regarding Anticancer Therapeutic Strategies

Adverse Effects and Safety Issues with Use of a/b-Arteether for Treatment of Severe Falciparum Malaria: A Case Report on Drug- Induced Dermatitis

Effect of Low-Molecular Fraction of Fish Peptide Albutrisan-NR on In Vitro Neurogenesis

Identification of Fosfomycin Heteroresistance Among Multidrug-Resistant Enterobacteriaceae Urinary Isolates

Fosfomycin is an orally bioavailable bactericidal agent which concentrates significantly in urine and is being increasingly prescribed for patients with Multidrug Resistant Enterobacteriaceae (MDRE) urinary isolates. According to the Clinical and Laboratory Standards Institute (CLSI), disc diffusion (DD) and agar dilution (AD) are the standards for fosfomycin susceptibility testing for urinary Escherichia coli and Enterococcus faecalis isolates, whereas the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines suggest both AD and broth microdilu- tion (BD), but not DD. A prospective study was done in the Department of Microbiology in a tertiary care teaching hospital in Kolkata. MDRE urinary isolates that were resistant to oral and third-generation cephalosporins, either ciprofloxacin or levofloxacin and either of cotrimoxazole or nitrofurantoin were included in the study and tested further for fosfomycin. DD was carried out on Mueller-Hinton agar (MHA) supplemented with 25 µg/ml G6P with 50 and 200 µg discs. E-test was carried out on the same medium with drug concentrations ranging from 0.064 to 1024 µg/ml. Broth dilution was carried out on G6P supplemented Mueller Hinton broth with drug concentrations ranging from 0.25 to 1024 µg/ml. A total of 723 urine samples were obtained in a 2-month period, which yielded 79 Enterobacteriaceae, out of which 30 were MDRE. About 26 (86.67%) of these isolates were susceptible to fosfomycin by CLSI criteria and 25 (83.33%) by EUCAST criteria for minimum inhibitory concen- tration (MIC) by E-test and broth dilution. Only 4 (13.33%) were resistant to fosfomycin by DD. However, heteroresistant colonies were found among 21 (70%) isolates by E-test. None of these were picked up by DD or BD. The MIC of fosfomycin was between 0.25 and 512 µg/ml. These heteroresistant colonies when further subjected to E-test and BD showed resistance with MIC 512 µg/ml, depicting prevalence of heteroresist- ance. E-test can be used as a simple and effective screening method for identifying the fosfomycin heteroresistance and in turn changing the myth of the so high susceptibility rates among MDRE.

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Impact of Implementation of Additional Endoscopy List on Hospital Inpatient Length of Stay

Clinical and Demographic Characteristics of Older Inflammatory Bowel Disease Patients

There is limited data describing management of older Australians with inflammatory bowel disease (IBD). The prevalence of IBD in the elderly is increasing due to an aging population and increasing overall incidence, which presents challenges in management due to comorbidities and polypharmacy. The aim of the study was to describe demographic and clinical characteristics, and management of IBD in older patients. Around 100 consecutive patients (n = 100) aged above 60 years and attending the IBD outpatient clinic of Fiona Stanley Hospital from January 2019 were selected. Demographic and clinical information were compiled from the digital medical record. Around 59 patients had Crohn’s disease (CD), 39 had ulcerative colitis (UC) and 2 unclassified IBD (IBD-U). Around 75% of patients had a Montreal classification recorded, which is a recommended standard of care. For both CD and UC, no patients had onset of symptoms <17 years old, and the majority had symptom onset after 40 years of age (CD—56%, UC—52%). Around 39% of CD patients had undergone at least one surgery, and 5% a second operation. No UC patients had undergone surgery. 5’Aminosalicylates (59%), antitumor necrosis factor alpha (33%), thiopurines (22%), and vedolizumab (11%) were the most common current treatments. Around 9% of patients were currently taking steroids while 36% had previously taken cor- ticosteroids. Immunosuppressive events were recorded, if they occurred, after treatment with steroids, immunomodulatory or biologic agents. Two patients had melanoma, 12 nonmelanoma skin cancer, 3 solid organ tumors (2 prostate adenocarcinoma and 1 bladder transitional cell carcinoma), 3 latent tuberculosis, 1 myelodysplasia, and 1 septic arthritis. Around 14% of the patients had osteoporosis or osteopenia; 43% of these had prior corticosteroid exposure; however, there was a low rate of bone densitometry. Most patients both with CD and UC were diagnosed over 40. Biologics were the most common treatment category in keeping with the aim of achieving deep remission.

Volume 6,Issue 2, 2020

Molecular Docking Studies of Podophyllotoxin and Its Derivatives against Metabolic Enzymes Regarding Anticancer Therapeutic Strategies

Adverse Effects and Safety Issues with Use of a/b-Arteether for Treatment of Severe Falciparum Malaria: A Case Report on Drug- Induced Dermatitis

Effect of Low-Molecular Fraction of Fish Peptide Albutrisan-NR on In Vitro Neurogenesis

Identification of Fosfomycin Heteroresistance Among Multidrug-Resistant Enterobacteriaceae Urinary Isolates

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Impact of Implementation of Additional Endoscopy List on Hospital Inpatient Length of Stay

Clinical and Demographic Characteristics of Older Inflammatory Bowel Disease Patients

Assessment of Thyroid Profile of Type 1 and Type 2 Diabetes Mellitus Patients and Patients with Diabetic Complications

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