10.18639/RABM.2015.01.156935
Original Research Article
Aug 21, 2015
The present study is designed to investigate the anti-inflammatory potential of N-acetylcysteine (NAC) against carbosulfan (CB)-induced hepatic dysfunction in rats. Rats exposed to CB and NAC were examined for toxicity by assessing various biochemical alteration, inflammation (interferon gamma and leucocyte counts), and peroxidation marker, including in liver. Significant increases of blood alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma glutamyltransferase (GGT) were detected in CB-treated rats. In addition, the level of pro-oxidative marker, such as malondialdehyde (MDA), was also increased. According to the results, rats exposed to CB showed a significant alteration in hepatic enzymes and an increase in the accumulation of lipid peroxidation index; also, CB induced an increase in pro-inflammatory cytokine in CB-treated rats when compared with their respective controls. Interestingly, administration of NAC to CB-treated rats attenuates the toxicity of CB, objectified by biochemical and oxidative improvement of liver. Thus, the present study reports for the first time that NAC could be a promising therapeutic agent against CB-induced liver impairment.
10.18639/RABM.2015.01.155696
Cancer and Oncology
Jun 06, 2015
Intestinal-type sinonasal adenocarcinoma accounts for about 3% of cancers of the upper aero-digestive tract. It is commonly seen in men in the age group of 55-60 years. We present the case of a 60-year-old woman having extensive disease in the right half of the nasal cavity extending to the dura of the anterior cranial fossa, and the right orbital contents. The patient was given induction chemotherapy to make the condition surgically amenable, but the regression was modest, and hence she has been put on concurrent chemo-radiotherapy.
10.18639/RABM.2015.01.95230
Toxicology and Pharmacology
Mar 13, 2015
The present study investigated the protective effects of N-acetylcysteine (NAC), is widely known as an antidote to acetaminophen overdose, on carbosulfan (CB)-induced hematotoxicity and oxidative stress in male rats. CB was administered at a dose of 25 mg/kg or simultaneously administered with NAC (2 g/l) for 30 days. Results of hematological examination showed that red blood cells, hematocrite, hemoglobin, and reticulocytes levels were significantly lower in CB-exposed rats compared with those in the control. Administration of CB caused a significant increase in the superoxide dismutase and catalase activities. However, the glutathione (GSH) and thiols group (TSH) levels were significantly increased as well as GSH S-transferase activity and levels of glutathione peroxidase on erythrocytes of males rats compared with those in the control. Also, CB-treated rats showed significant elevation in lipid peroxidation (LPO) and acetylcholinesterase (AChE) on erythrocytes in comparison with the control. Co-administration with NAC exhibited chemoprotective effects against CB-mediated hematotoxicity, augmented erythrocyte antioxidant status, and prevented the induction of anemia.
10.18639/RABM.2015.01.94785
Original Research Article
Feb 05, 2015
This study aimed to investigate the effect of lead acetate on the fallopian tube of adult mice and the possible effect of garlic extract in a Laboratory Based Randomized Control Trial. In this study, 30 female BALBc mice were selected and randomly divided into three groups. Ten animals were placed in each group. Group A being the control received only the laboratory diet. Group B was given lead acetate at a dose of 30 mg/kg/day. Group C was given lead acetate at 30 mg/kg/day and garlic extract at 500 mg/kg/day. All treatments were given through oral gavage tube for 60 days. The mice were sacrificed and dissected at the end of 60 days. The fallopian tubes were carefully dissected out and fixed in 10% formalin for routine histological examination. The histological findings in experimental group B showed increase in epithelial height, whereas no such findings were observed in group A and there was slight increase in height in group C. The lead acetate affected the epithelial height in lead acetate treated group which improved when cotreated with garlic extract.
10.18639/RABM.2014.01.66172
Agriculture and Allied Sciences
Jul 09, 2014
One of the many new risks that effecting the early societies is the continuous exposure to pollutants, namely, heavy metals. Mercury (Hg) is perhaps the metal which has attracted the most attention in soil science and plant nutrition due to its potential toxicity to ecosystem. In the present study, the toxic effect of mercury was determined by morphological and physiological parameter on plant Phaseolus vulgaris. In germination studies, parameters such as germination percentage, root length, and shoot length were decreased with increasing dose of mercuric chloride (HgCl2) concentrations. Mercury also showed inhibition property towards physiological parameters such as chlorophyll, protein, nitrate, and endogenous pool. Higher concentrations of HgCl2 were found to be more toxic.
