The soaring cases of coronavirus pandemic coupled with unpredictable climatic variations posed danger to human lives and food security. This work examined “Relationship between climate change and food security in sub-Saharan Africa.” Using the Generalized Method of Moments technique with preliminary diagnostic tests on panel data across the 17 sub-Sahara African countries, the dependent variable is agricultural output, while the independent variables are temperature, rainfall, government expenditure on agriculture, inflation, exchange rate, gross fixed capital formation, and labor force. The findings revealed that climate change exerts negative impact on food security through temperature variations which degenerated during the period under review. The results also showed positive significant impact on government expenditure which increased during the period. The work recommended that government should embark on massive productive investments to reinvigorate and re-engineer the economy. The government and appropriate agencies should also put in place hybrid technology of high yield crops adaptive to change in climate as well as effective mechanism for food storage to secure food for the future.