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Predominance of Nosocomial Pathogens among Patients with Post-Operative Wound Infections and Evaluation of the Antibiotic Susceptibility Patterns in Rural Hospitals in Bangladesh

Authors: Mohammad Z Abedin et al.

DOI : 10.18639/RABM.2020.9800005

Section : Microbiology and Immunology

Published Date : Nov 16, 2020

Abstract

Wound infection is considered one of the most common nosocomial infections all over the world. So, the aims and objectives of this study are to identify the pathogenic agents of wound infection infecting hospital admitted patients and commonly used antimicrobial susceptibility profiles. A total of 91 samples were collected for the study. The cultural analysis was done by phenotypic examination as well as Gram staining and biochemical examination to identify the isolates. Finally, antibiotic sensitivity was tested against conventionally used antibiotics. All the samples were aseptically collected from different hospitals in the Tangail area and tests were done in the Lab Zone and Hormone Center, Tangail, Bangladesh between January 2019 and June 2019. 84(92.3%) of the total samples yielded a positive culture and only 7(7.7%) samples were negative growth. Gram-Negative bacteria 64(76.2%) showed more prevalence than Gram-Positive bacteria 20(23.8%). The most predominant isolates were Pseudomonas species 54(64.3%) in this study though Staphylococcus species 20(23.8%), Proteus species 7(8.3%), and Klebsiella species 3(3.6%) were also found. Like most of the previous reports, Pseudomonas species was predominant; this is also corroborated in this study. However, the antimicrobial result of the detected organisms differed compared to studies that were previously done. The isolates were found to be resistant to most common oral antibiotics used, such as Cefuroxime, Colistin, Cephradine, Ciprofloxacin, Ceftazidime, and Ceftriaxone which was alarming. The pathogens showed remarkable sensitivity against Gentamicin and Meropenem. This research needs further work for validating more reliability. This study is designed to provide information on pathogens which are isolated from wound suspected of wound infection hospital admitted patients in Bangladesh and their antibiotic susceptibility profile against locally available antibiotics which are frequently prescribed by the doctors to find a suitable antibiotic for wound infections.


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