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Recent Advances in Biology and Medicine
open access

Effect of Low-Molecular Fraction of Fish Peptide Albutrisan-NR on In Vitro Neurogenesis

DOI : 10.18639/RABM.2020.1101035

Section : Original Research Article

Published Date : Apr 30,2020

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Abstract

The effect of the Albutrisan-NR substrate on the differentiation of the primary brain culture of aging rats and on the culture of the rabbit vibrissa dermal papilla was studied. The substance is a hydrolysate of fish tissue with a molecular weight of up to 5 kDa. It was found that adding 2% of the substance to the culture medium stimulates the growth and differentiation processes in rat brain cells. The possibility of using the substance as a growth factor for 3D cultivation of pluripotent dermal papilla cells and maintaining an uncommitted state was demonstrated. The use of Albutrisan-NR as a trophic factor in neuronal induction of dermal papilla cells was also shown.

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