Colorectal Cancer (CRC), which is one of themost commonly diagnosed cancers worldwide, threatens human health. Since the pathologicalmechanism of CRC is not entirely understood, there are many challenges in preventing, diagnosing, and treating this disease. Long non-coding RNAs (LncRNAs) have recently gained attention due to their potential role in various stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immune responses, cell cycle, and Epithelial Mesenchymal Transition (EMT). The role of long non-coding RNA Regulator of Reprogramming (ROR) in cellular reprogramming has been studied in this research. After extracting and preparing RNA from 100 cancerous and 100 non-cancerous tissues, the expression changes of Linc-ROR and all samples were analyzed with the Real time PCR technique. The statistical test results showed that Linc-ROR has a significant expression increase in tumor samples compared to non-tumor samples. According to the obtained results, the expression of the Linc- ROR gene is expected to be related to tumorigenesis and is very important in inhibiting apoptosis during cell stress.
