Pijusaballi Rasa (PJB) is an Ayurvedic preparation used as a traditional medicine in the treatment of edema in the rural population in Bangladesh. The acute pharmacological test of PJB recorded no death or any signs of toxicity even at the highest dose of 4000 mg/kg body weight. To find out the effect of chronic administration of PJB on serum chemistry profile, it was administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/kg. After 28 days of chronic administration of the PJB preparation, the serum chemistry profile, composed of a battery of tests, allowed for evaluation of several body systems and assessment of metabolic disturbances. The results of the effect of chronic administration of PJB on serum chemistry profile were as follows. There was a statistically highly significant (p = 0.003) decrease in the total protein in the serum of the male rats (9.45% decrease). There was a statistically highly significant (p = 0.010) increase in the albumin level in the serum of the male rats (24.66% increase). There was a statistically very highly significant (p = 0.001) decrease in the globulin level in the serum of the male rats (45.50% decrease). There was a statistically significant (p = 0.015) increase in the albumin/globulin ratio in the serum of the male rats (175.19% increase). There was a statistically significant (p = 0.014) increase in the uric acid level in the serum of the male rats (25.16% increase).
