Short Description: "Biology and Medicine" (also referred to as BLM or BAM) is a peer-reviewed, ONLINE HYBRID OPEN ACCESS journal, efficiently publishing original and relevant articles in thrust areas of research in Biological and Medical Sciences.
E-ISSN: 0974-8369
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Publisher: Walsh Medical Media
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City: London
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Country: United Kingdom
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Email: [email protected]
Short Communication
May 29, 2023
Cancer is a complex disease that occurs when abnormal cells in the body begin to grow and divide uncontrollably. This can result in the formation of tumors or the spread of cancerous cells throughout the body, leading to a range of symptoms and potential health complications. There are many different types of cancer, each with its own unique characteristics, behaviors, and risk factors
Research Article
May 16, 2023
The causes of endotheliopathy are multifactorial and trauma dependent, and the temporal mechanistic link that it has with Acute Traumatic Coagulopathy (ATC) has yet to be fully determinutesed. Therefore, we sought to define early characteristics and markers of endotheliopathy in two rat models, a time-course of acute lethal hemorrhage shock and polytrauma with hemorrhagic shock, to answer the following questions: (1) How soon can elevated biomarkers of endotheliopathy be detected in non-survivable (decompensated) hemorrhagic shock; (2) Does extended hemorrhage time and accumulated hemorrhage impact biomarker levels; and (3) Does the addition of polytrauma contribute to the further elevation of said biomarkers? In this study, we delineated a significant, acute elevation in end plasma levels of syndecan-1, thrombomodulin, and heparan sulfate, whose shedding patterns are a function of time as well as total hemorrhage volume vs. the addition of polytrauma. Additionally, we found that correlation of syndecan-1 and thrombomodulin to lactate levels and prothrombin times at trauma end revealed a potential for these markers to acutely predict downstream consequences of these trauma indications. Our results are of great relevance to the continued effort towards the identification and characterization of vascular dysfunction for early interventions in combat casualty care.
Research Article
Mar 20, 2023
Recent preclinical data suggest that Glucagon-like Peptide-1 Receptor Agonist (GLP1RA) possesses cardioprotective properties against the pathophysiology of Hypertension (HT). We sought to unravel the potential therapeutic application of GLP1RA in a clinically relevant large animal model of hypertensive Cardiomyopathy (hCMP). We used a combination of Angiotensin II (Ang II) and Deoxycorticosterone Acetate (DOCA) pellets to induce sustained HT status and establish hCMP in porcine model. Changes in cardiac echocardiography, invasive hemodynamic parameters, neurohumoral biomarkers and inflammation- related cytokines were investigated in 23 adult pigs, among which 6 were serving as control, 9 were induced with HT, and the remaining 8 were HT-induced with GLP1RA treatment. Eight weeks after the study initiated, HT pigs have developed sustained high Blood Pressure (BP) at both systole and diastole. Phenotype of hCMP has also become significant as impairment in systolic/diastolic function left ventricular remodeling and cardiac hypertrophy was determined by echocardiogram and invasive hemodynamics. Additionally, blood Norepinephrine (NE) content, venoarterial NE gradient and pro-inflammatory cytokines in HT pigs were increased. GLP1RA treatment halted the elevation in BP, left ventricular remodeling and cardiac hypertrophy development; preserved the left ventricular systolic/diastolic function; reduced the venoarterial NE gradient and decreased pro-inflammatory cytokine levels in the hCMP pigs at 18 weeks. Our results demonstrate that GLP1RA treatment has a remarkable effect effect on reducing blood pressure and inflammation, and improving left ventricular function, thus indicating its potential therapeutic value in hypertension-induced heart failure in a large animal model of hCMP.
